Luteinizing Hormone to Follicle-Stimulating Hormone Ratio Significantly Correlates With Androgen Level and Manifestations Are More Frequent With Hyperandrogenemia in Women With Polycystic Ovary Syndrome

Background: Altered luteinizing hormone to follicle-stimulating (LH-FSH) ratio and hyperandrogenism are two important pathophysiological characteristics of polycystic ovary syndrome (PCOS). The aim this study was evaluate the relationship LH-FSH with androgen in women PCOS. Methods: This cross-sectional included 550 newly detected reproductive aged PCOS (mean ± standard deviation (SD): age 23.14 4.80 years; body mass index (BMI) 27.64 5.34 kg/m 2 ) according revised Rotterdam criteria. Relevant clinical history, physical examination ultrasonogram ovaries were done for each participant. Fasting serum LH, FSH total testosterone (TT) measured by chemiluminescent microparticle immunoassay from blood collected during follicular phase menstrual cycle. Results: More than two-thirds (n = 389, about 71%) had altered (cut-off > 1.0) 43% 234) hyperandrogenemia (TT 46 ng/dL). Frequency none variables or ovarian morphology differed statistically between groups without (NS all). Serum TT positively correlated (r 0.139, P 0.001). However, irregularity (P 0.002), 0.045), diabetes mellitus 0.017), obesity 0.009) hirsutism < 0.001) higher frequency hyperandrogenic group. predictive association (odds (OR) (95% confidence interval (CI)): 1.09 (1.02 - 1.16), 0.02) (OR CI): 1.15 (1.03 1.28), Conclusions: androgenemia significantly correlate manifestations more frequent rather ratio. J Endocrinol Metab. 2021;11(1):14-21 doi: https://doi.org/10.14740/jem716